Early Biological Aging and Fetal Exposure to High and Low Ambient Temperature: A Birth Cohort Study | Semantic Scholar (2024)

It is shown that increasing nest temperature by ca.

It was found that between individuals, an interquartile range (IQR) increase in daily air temperature was associated with shorter leukocyte telomere length at lags 0–1, 2–6, 0– 6, and 0–13 days.

Functional enrichment analysis based on the selected CpGs in the two models revealed GLUT4 translocation and immune cell signaling pathways, respectively and are potential novel targets of further investigation of telomere biology and aging.

The hypothesis that in cattle, early life telomere length is influenced by prenatal factors is supported and the results suggest that selecting heifers born in winter out of young dams might contribute to increased longevity in dairy cattle.

These findings suggest that having a high BT between 35°C and 37.5°C (95°F and 99°F) may be detrimental for obese individuals in terms of biological aging.

To understand the role of telomeres biology in ageing-related diseases, it is essential to expand telomere research to newborns and children and seek further insight into the underlying causes of the variation in TL due to ancestry and geographical location.

Insight is provided into molecular aging signatures at the start of life, including their interrelations and determinants, showing that cord blood DNAm age is inversely associated with global methylation and mtDNA content but not with newborn telomere length.

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The observed telomere loss in newborns by prenatal air pollution exposure indicates less buffer for postnatal influences of factors decreasing telomeres length during life, and improvements in air quality may promote molecular longevity from birth onward.

An inverse association between exposure to air pollution during the second trimester of pregnancy and relative telomere length (RTL) in cord blood samples and placentae is reported, which theorize that maternal exposure to pollution during this period could help elucidate the association of environmental exposures with telomeres length (TL) dynamics in utero.

Maternal pre-pregnancy BMI is associated with shorter newborn telomere lengths as reflected by cord blood and placental telomeres, and these findings support the benefits of a pre-Pregnancy healthy weight for promoting molecular longevity from early life onwards.

The findings indicated that increased maternal urinary cadmium was associated with shortened relative cord blood TL, which provides more evidence of the negative effects of environmental cadMium exposure and suggest that accelerated aging or cad mium-related diseases may begin in early life.

Longitudinal evidence of telomere length tracking from birth to adulthood shows inverse associations of residential traffic exposure in association with telomer length at birth as well as accelerated telomeres shortening in the first two decades of life.

The findings suggest that fetal telomere length exhibits developmental plasticity, and provide evidence that maternal nutrition may exert a ‘programming' effect on this system.

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